rs113067418 - CASP3P1 - LINC01788
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association study of seasonal affective disorder - Unknown journal (n.d.) · Unknown authors · PubMed 30217971
ABSTRACT: Family and twin studies have shown a genetic component to seasonal affective disorder (SAD). A number of candidate gene studies have examined the role of variations within biologically relevant genes in SAD susceptibility, but few genome-wide association studies (GWAS) have been performed to date. The authors aimed to identify genetic risk variants for SAD through GWAS. The authors performed a GWAS for SAD in 1380 cases and 2937 controls of European-American (EA) origin, selected from samples for GWAS of major depressive disorder and of bipolar disorder. Further bioinformatic analyses were conducted to examine additional genomic and biological evidence associated with the top GWAS signals. No susceptibility loci for SAD were identified at a genome-wide significant level. The stro
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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vitamin D serum levels Moderate
Seasonal depression may correlate with reduced sunlight-dependent vitamin D synthesis; variant carriers may have increased susceptibility
Annual 25-hydroxyvitamin D testing, particularly before autumn; maintain levels 30-50 ng/mL
Lifestyle
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bright light exposure during darker months Moderate
CASP3P1-LINC01788 variant associated with seasonal depression; light exposure supports circadian rhythm and mood regulation
30-60 minutes daily at 2500-10000 lux, especially October through March
Screening
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seasonal mood pattern assessment with healthcare provider Moderate
Genetic variant associated with seasonality and depression indicates need for systematic seasonal mood monitoring