rs113029345 - CYP2A6 - CYP2A7
Magnitude 2.2 · 2 studies on file
Reported associations
-
Novel Association of Genetic Markers Affecting CYP2A6 activity and Lung Cancer Risk - Unknown journal (n.d.) · Unknown authors · PubMed 27488534
ABSTRACT: Metabolism of nicotine by cytochrome CYP2A6 is a suspected determinant of smoking dose and, consequently, lung cancer risk. We conducted a genome-wide association study (GWAS) of CYP2A6 activity, as measured by the urinary ratio of trans-3′-hydroxycotinine and its glucuronide conjugate over cotinine (total 3HCOT/COT), among 2,239 smokers in the Multiethnic Cohort (MEC) study. We identified 248 CYP2A6 variants associated with CYP2A6 activity (p<5×10−8). CYP2A6 activity was correlated (r=0.32, p<0.0001) with total nicotine equivalents (a measure of nicotine uptake). When we examined the effect of these variants on lung cancer risk in the Transdisciplinary Research in Cancer of the Lung (TRICL) consortium GWAS dataset (13,479 cases, 43,218 controls), we found that the vast majo
-
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry - Unknown journal (n.d.) · Unknown authors · PubMed 26634245
ABSTRACT: Background Pulmonary function decline is a major contributor to morbidity and mortality among smokers. Post bronchodilator FEV1 and FEV1/FVC ratio are considered the standard assessment of airflow obstruction. We performed a genome-wide association study (GWAS) in 9919 current and former smokers in the COPDGene study (6659 non-Hispanic Whites [NHW] and 3260 African Americans [AA]) to identify associations with spirometric measures (post-bronchodilator FEV1 and FEV1/FVC). We also conducted meta-analysis of FEV1 and FEV1/FVC GWAS in the COPDGene, ECLIPSE, and GenKOLS cohorts (total n = 13,532). Results Among NHW in the COPDGene cohort, both measures of pulmonary function were significantly associated with SNPs at the 15q25 locus [containing CHRNA3/5, AGPHD1, IREB2, CHRNB4] (low
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
-
Daily cigarette quantity if currently smoking Moderate
Fast nicotine metabolism from the C allele may cause you to smoke more cigarettes daily than intended to maintain nicotine levels.
Track daily cigarette consumption; use tracking data to inform reduction and cessation strategies.
Screening
-
Lung cancer screening consultation Moderate
C allele increases CYP2A6 activity, causing faster nicotine metabolism, leading smokers to increase cigarette consumption and carcinogen exposure.
Discuss with healthcare provider timing, frequency, and methods for lung cancer screening (e.g. low-dose CT).