rs113020870 - AGRN

Magnitude 2.0 · 1 study on file

Reported associations

• A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease - Unknown journal (n.d.) · Unknown authors · PubMed 34493870

  ABSTRACT: Late-onset Alzheimer's disease is a prevalent age-related polygenic disease that accounts for 50-70% of dementia cases. Currently, only a fraction of the genetic variants underlying Alzheimer's disease have been identified. Here we show that increased sample sizes allowed for identification of seven previously unidentified genetic loci contributing to Alzheimer's disease. This study highlights microglia, immune cells, and protein catabolism as relevant to late-onset Alzheimer's disease, while identifying and prioritizing previously unidentified genes of potential interest. We anticipate that these results can be included in larger meta-analyses of Alzheimer's disease to identify further genetic variants which contribute to Alzheimer's pathology. FULL TEXT: [INTRO]

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