rs113018692 - LYZL6 - CCL16
Magnitude 4.5 · 1 study on file
Reported associations
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Identification of susceptibility loci for cardiovascular disease in adults with hypertension, diabetes, and dyslipidemia - Unknown journal (n.d.) · Unknown authors · PubMed 33632238
ABSTRACT: Background Hypertension (HTN), diabetes mellitus (DM), and dyslipidemia (DL) are well-known risk factors of cardiovascular disease (CVD), but not all patients develop CVDs. Studies have been limited investigating genetic risk of CVDs specific to individuals with metabolic diseases. This study aimed to identify disease-specific and/or common genetic loci associated with CVD susceptibility in chronic metabolic disease patients. Methods We conducted a genome-wide association study (GWAS) of a multiple case-control design with data from the City Cohort within Health EXAminees subcohort of the Korean Genome and Epidemiology Study (KoGES_HEXA). KoGES_HEXA is a population-based prospective cohort of 173,357 urban Korean adults that had health examinations at medical centers. 42,393 pa
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic stroke risk and cardiovascular prevention strategy Moderate
Variant confers increased ischemic stroke susceptibility; physician assessment can identify other modifiable risk factors and recommend personalized prevention approaches
Discuss genetic stroke risk with your physician and develop cardiovascular prevention plan
Screening
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Blood pressure and cardiovascular screening Moderate
Variant associated with 1.51-fold increased ischemic stroke risk in genome-wide association study of 16,307 individuals
Annual blood pressure checks; consider more frequent monitoring if family history of cardiovascular disease