Expressive

rs11300113 - ARK2N

Magnitude 2.2 · 1 study on file

Reported associations

  • A cross-population atlas of genetic associations for 220 human phenotypes. - Nature genetics (2021) · Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, Ishigaki K, Suzuki A, Suzuki K, Obara W, Yamaji K, Takahashi K, Asai S, Takahashi Y, Suzuki T, Shinozaki N, Yamaguchi H, Minami S, Murayama S, Yoshimori K, Nagayama S, Obata D, Higashiyama M, Masumoto A, Koretsune Y, Ito K, Terao C, Yamauchi T, Komuro I, Kadowaki T, Tamiya G, Yamamoto M, Nakamura Y, Kubo M, Murakami Y, Yamamoto K, Kamatani Y, Palotie A, Rivas MA, Daly MJ, Matsuda K, Okada Y · PubMed 34594039

    Current genome-wide association studies do not yet capture sufficient diversity in populations and scope of phenotypes. To expand an atlas of genetic associations in non-European populations, we conducted 220 deep-phenotype genome-wide association studies (diseases, biomarkers and medication usage) in BioBank Japan (n = 179,000), by incorporating past medical history and text-mining of electronic medical records. Meta-analyses with the UK Biobank and FinnGen (n = 628,000) identified ~5,000 new loci, which improved the resolution of the genomic map of human traits. This atlas elucidated the landscape of pleiotropy as represented by the major histocompatibility complex locus, where we conducted HLA fine-mapping. Finally, we performed statistical decomposition of matrices of phenome-wid

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • low glycemic index dietary pattern Moderate

    Individuals with genetic predisposition to higher hemoglobin A1c benefit from diet that minimizes blood glucose spikes.

    Emphasize whole grains, legumes, and non-starchy vegetables; limit refined carbohydrates and added sugars

Exercise

  • regular structured physical activity Moderate

    Exercise improves insulin sensitivity and glucose homeostasis, directly improving hemoglobin A1c in those with genetic predisposition to elevation.

    At least 150 minutes moderate-intensity aerobic activity and 2 sessions resistance training per week

Screening

  • hemoglobin A1c levels Moderate

    Genetic variant rs11300113-A is robustly associated with elevated hemoglobin A1c; monitoring enables early detection of metabolic dysregulation.

    Hemoglobin A1c screening annually starting at age 30, or more frequently if additional risk factors present