Expressive

rs112997627 - RPS26P8 - LINC02210

Magnitude 4.5 · 2 studies on file

Reported associations

  • The genetic architecture of the corpus callosum and its genetic overlap with common neuropsychiatric diseases. - Journal of affective disorders (2023) · Chen SJ, Wu BS, Ge YJ, Chen SD, Ou YN, Dong Q, Feng J, Cheng W, Yu JT · PubMed 37164063

    The corpus callosum (CC) is the main structure transferring information between the cerebral hemispheres. Although previous large-scale genome-wide association study (GWAS) has illustrated the genetic architecture of white matter integrity of CC, CC volume is less stressed. Using MRI data from 33,861 individuals in UK Biobank, we conducted univariate and multivariate GWAS for CC fractional anisotropy (FA) and volume with PLINK 2.0 and MOSTest. All discovered SNPs in the multivariate framework were functionally annotated in FUMA v1.3.8. In the meanwhile, a series of gene property analyses was conducted simultaneously. In addition, we estimated genetic relationship between CC metrics and other neuropsychiatric traits and diseases. We identified a total of 36 and 82 significant genomic loci f

  • Genome-wide association study in almost 195,000 individuals identifies 50 previously unidentified genetic loci for eye color - Unknown journal (n.d.) · Unknown authors · PubMed 33692100

    ABSTRACT: A GWAS including 192,986 European and 1636 Asian participants identifies 50 novel discrete associations with eye color. Human eye color is highly heritable, but its genetic architecture is not yet fully understood. We report the results of the largest genome-wide association study for eye color to date, involving up to 192,986 European participants from 10 populations. We identify 124 independent associations arising from 61 discrete genomic regions, including 50 previously unidentified. We find evidence for genes involved in melanin pigmentation, but we also find associations with genes involved in iris morphology and structure. Further analyses in 1636 Asian participants from two populations suggest that iris pigmentation variation in Asians is genetically similar to Europeans,

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