rs112972174 - COL4A1
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma - Unknown journal (n.d.) · Unknown authors · PubMed 29785010
ABSTRACT: Glaucoma is the leading cause of irreversible blindness globally. Despite its gravity, the disease is frequently undiagnosed in the community. Raised intraocular pressure (IOP) is the most important risk factor for primary open-angle glaucoma (POAG). Here we present a meta-analysis of 139,555 European participants that identified 112 genomic loci associated with IOP, 68 of which are novel. These loci suggest a strong role for angiopoietin-receptor tyrosine kinase signaling, lipid metabolism, mitochondrial function and developmental processes underlying risk for elevated IOP. In addition, 48 of these loci were associated with glaucoma in an independent cohort, 14 of which at a Bonferroni-corrected threshold. Regression-based glaucoma prediction models had an area under Receiving O
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Discuss elevated intraocular pressure risk with eye care provider Moderate
rs112972174 in COL4A1 increases intraocular pressure; ophthalmologist can establish optimal monitoring frequency
Exercise
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Aerobic exercise to manage intraocular pressure Moderate
COL4A1 rs112972174 variants increase intraocular pressure; aerobic exercise reduces IOP
30 minutes moderate-intensity aerobic activity 4-5 days per week
Screening
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Regular intraocular pressure monitoring Moderate
COL4A1 rs112972174 risk alleles increase intraocular pressure, a primary risk factor for glaucoma
Annual or biennial intraocular pressure measurement starting at age 40