rs112915006 - MOV10L1 - PANX2
Magnitude 2.2 · 1 study on file
Reported associations
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Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps - Unknown journal (n.d.) · Unknown authors · PubMed 30297969
ABSTRACT: We aggregated genome-wide genotyping data from 32 European-descent GWAS (74,124 T2D cases, 824,006 controls) imputed to high-density reference panels of >30,000 sequenced haplotypes. Analysis of ˜27M variants (˜21M with minor allele frequency [MAF]<5%), identified 243 genome-wide significant loci (p<5x10-8; MAF 0.02%-50%; odds ratio [OR] 1.04-8.05), 135 not previously-implicated in T2D-predisposition. Conditional analyses revealed 160 additional distinct association signals (p<10-5) within the identified loci. The combined set of 403 T2D-risk signals includes 56 low-frequency (0.5%≤MAF<5%) and 24 rare (MAF<0.5%) index SNPs at 60 loci, including 14 with estimated allelic OR>2. Forty-one of the signals displayed effect-size heterogeneity between BMI-unadjusted and adjusted anal
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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Emphasize whole grains, legumes, and non-starchy vegetables Moderate
Lower glycemic load diet reduces insulin demand in those with genetic Type 2 diabetes predisposition
Limit refined grains and added sugars; prioritize fiber-rich whole foods
Exercise
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Regular aerobic and resistance exercise Moderate
Physical activity improves insulin sensitivity and glucose metabolism independent of weight loss
150 minutes weekly moderate aerobic activity plus 2 days weekly resistance training
Screening
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Type 2 diabetes screening Moderate
G allele at rs112915006 is associated with 8% increased Type 2 diabetes risk in large cohort
Annual fasting glucose and HbA1c testing