rs1128905 - GPSM1
Magnitude 2.2 · 1 study on file
Reported associations
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Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci - Unknown journal (n.d.) · Unknown authors · PubMed 23749187
ABSTRACT: Ankylosing spondylitis is a common, highly heritable inflammatory arthritis affecting primarily the spine and pelvis. In addition to HLA-B*27 alleles, 12 loci have previously been identified that are associated with ankylosing spondylitis in populations of European ancestry, and 2 associated loci have been identified in Asians. In this study, we used the Illumina Immunochip microarray to perform a case-control association study involving 10,619 individuals with ankylosing spondylitis (cases) and 15,145 controls. We identified 13 new risk loci and 12 additional ankylosing spondylitis-associated haplotypes at 11 loci. Two ankylosing spondylitis-associated regions have now been identified encoding four aminopeptidases that are involved in peptide processing before major histocom
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Discuss genetic risk for ankylosing spondylitis Moderate
Variant rs1128905 confers increased genetic susceptibility to ankylosing spondylitis based on large GWAS study.
Mention this genetic finding at next healthcare visit
Screening
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Monitor for ankylosing spondylitis symptoms Moderate
Genetic variant increases risk for ankylosing spondylitis, an inflammatory joint condition affecting the spine.
Report back pain, morning stiffness, or reduced spinal flexibility to healthcare provider