Expressive

rs112883759 - IMPA1P1

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures - Unknown journal (n.d.) · Unknown authors · PubMed 40436827

    ABSTRACT: Genome-wide association studies (GWAS) have predominantly focused on European ancestry populations, limiting biological discoveries across diverse populations. Here we report GWAS findings from 153,950 individuals across 36 quantitative traits in the Korean Cancer Prevention Study-II (KCPS2) Biobank. We discovered 301 previously unreported genetic loci in KCPS2, including an association between thyroid-stimulating hormone and CD36. Meta-analysis with the Korean Genome and Epidemiology Study, Biobank Japan, Taiwan Biobank, and UK Biobank identified 4588 loci that were not significant in any contributing GWAS. We describe differences in genetic architectures across these East Asian and European samples. We also highlight East Asian specific associations, including a known pleiotrop

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • Fasting triglyceride levels Moderate

    This SNP's risk allele is associated with higher triglyceride levels, a modifiable cardiovascular risk factor.

    Annual fasting lipid panel, or more frequently if triglycerides are elevated

Diet

  • Refined carbohydrates and added sugars Moderate

    Refined carbohydrates and sugars increase triglyceride levels; reducing them is particularly important for genetic predisposition to elevated triglycerides.

    Limit refined grains and added sugars; prioritize whole grains and complex carbohydrates

Exercise

  • Aerobic exercise Moderate

    Regular aerobic exercise reduces triglyceride levels; especially beneficial for those with genetic predisposition to elevation.

    150 minutes per week of moderate-intensity aerobic exercise