rs1128175 - PSORS1C3

Magnitude 2.0 · 1 study on file

Reported associations

• Causal association and shared genetics between telomere length and COVID-19 outcomes: New evidence from the latest large-scale summary statistics - Computational and structural biotechnology journal (2024) · Zhang J, Wen J, Dai Z, Zhang H, Zhang N, Lei R, Liu Z, Peng L, Cheng Q · PubMed 38882679

  ABSTRACT: Background Observational studies suggested that leukocyte telomere length (LTL) is shortened in COVID-19 patients. However, the genetic association and causality remained unknown. Methods Based on the genome-wide association of LTL (N = 472,174) and COVID-19 phenotypes (N = 1086,211-2597,856), LDSC and SUPERGNOVA were used to estimate the genetic correlation. Cross-trait GWAS meta-analysis, colocalization, fine-mapping analysis, and transcriptome-wide association study were conducted to explore the shared genetic etiology. Mendelian randomization (MR) was utilized to infer the causality. Upstream and downstream two-step MR was performed to investigate the potential mediating effects. Results LDSC identified a significant genetic association between LTL and all COVID-19 phe

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