rs112809490 - AQP7
Magnitude 4.5 · 1 study on file
Reported associations
-
Genome‐Wide Association Analyses of HPV16 and HPV18 Seropositivity Identify Susceptibility Loci for Cervical Cancer - Unknown journal (n.d.) · Unknown authors · PubMed 39891432
ABSTRACT: ABSTRACT Infection by high‐risk human papillomavirus is known to exacerbate cervical cancer development. The host immune response is crucial in disease regression. Large‐scale genetic association studies for cervical cancer have identified few susceptibility variants, mainly at the human leukocyte antigen locus on chromosome 6. We hypothesized that the host immune response modifies cervical cancer risk and performed three genome‐wide association analyses for HPV16, HPV18 and HPV16/18 seropositivity in 7814, 7924, and 7924 samples from the UK Biobank, followed by validation genotyping in the German Cervigen case‐control series of cervical cancer and dysplasia. In GWAS analyses, we identified two loci associated with HPV16 seropositivity (6p21.32 and 15q26.2), two loci asso
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
-
HPV vaccination eligibility and serology status Moderate
Genetic variant strongly associated with HPV18 seropositivity, indicating increased HPV18 exposure susceptibility.
Review HPV vaccination eligibility and serology status with healthcare provider.
Screening
-
HPV-related cancer screening Moderate
Association with HPV18 seropositivity indicates elevated prior exposure or infection risk.
Ensure cervical cancer screening and HPV-related cancer monitoring per standard protocols.