rs112783753 - TPSD1 - PRSS29P
Magnitude 2.2 · 1 study on file
Reported associations
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Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations - Unknown journal (n.d.) · Unknown authors · PubMed 36168886
ABSTRACT: Abstract Polygenic scores (PGS) can identify individuals at risk of adverse health events and guide genetics-based personalized medicine. However, it is not clear how well PGS translate between different populations, limiting their application to well-studied ethnicities. Proteins are intermediate traits linking genetic predisposition and environmental factors to disease, with numerous blood circulating protein levels representing functional readouts of disease-related processes. We hypothesized that studying the genetic architecture of a comprehensive set of blood-circulating proteins between a European and an Arab population could shed fresh light on the translatability of PGS to understudied populations. We therefore conducted a genome-wide association study with whole-genome
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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Baseline serum tryptase level Moderate
Carriers of the T allele have significantly elevated tryptase beta-2 levels, a biomarker of mast cell status and potential disorders.
Order serum total tryptase; normal baseline <11.4 ng/mL.
Discuss with your doctor
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Elevated tryptase genetic association and testing Moderate
This SNP has a strong GWAS signal for tryptase elevation; elevated tryptase can indicate mast cell activation disorders.