rs112724034 - PGAM5P1

Magnitude 2.2 · 1 study on file

Reported associations

• Genome Wide Association Study of the Rate of Cognitive Decline in Alzheimer's Disease - Unknown journal (n.d.) · Unknown authors · PubMed 23535033

  ABSTRACT: Background Substantial inter-individual variability exists in the disease trajectories of Alzheimer's disease (AD) patients. Some decline rapidly while others decline slowly and there are no known explanations for this variability. We describe the first genome wide association study to examine rate of cognitive decline in a sample of AD patients with longitudinal measures of cognition. Methods The discovery sample was 303 AD cases recruited in the AD Neuroimaging Initiative and the replication sample was 323 AD cases from the Religious Orders Study and Rush Memory and Aging Project. In the discovery sample, Alzheimer's Disease Assessment Scale-cognitive subscale responses were tested for association with genome-wide SNP data using linear regression. We tested the 65 most sign

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