Expressive

rs112706914 - AAMDC, INTS4

Magnitude 2.2 · 1 study on file

Reported associations

  • Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension. - Kidney international (2022) · Surapaneni A, Schlosser P, Zhou L, Liu C, Chatterjee N, Arking DE, Dutta D, Coresh J, Rhee EP, Grams ME · PubMed 35870639

    Investigations into the causal underpinnings of disease processes can be aided by the incorporation of genetic information. Genetic studies require populations varied in both ancestry and prevalent disease in order to optimize discovery and ensure generalizability of findings to the global population. Here, we report the genetic determinants of the serum proteome in 466 African Americans with chronic kidney disease attributed to hypertension from the richly phenotyped African American Study of Kidney Disease and Hypertension (AASK) study. Using the largest aptamer-based protein profiling platform to date (6,790 proteins or protein complexes), we identified 969 genetic associations with 900 unique proteins; including 52 novel cis (local) associations and 379 novel trans (distant) associatio

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Genetic risk for chronic kidney disease and hypertension Moderate

    GWAS association at p=5.00e-20 indicates genetic predisposition; personalized prevention strategies may reduce disease incidence

    Review family history of CKD and hypertension, discuss baseline risk assessment and preventive management options

Lifestyle

  • Hypertension prevention through lifestyle modification Moderate

    Genetic hypertension predisposition; evidence-based lifestyle interventions significantly reduce blood pressure in genetically susceptible individuals

    Exercise 150 min/week, DASH diet, BMI 18.5-25, sodium less than 2300mg/day, stress management

Screening

  • Annual kidney function and blood pressure assessment Moderate

    rs112706914 C allele is associated with chronic kidney disease and hypertension; genetic predisposition warrants early detection

    Annual blood pressure measurement, serum creatinine, and eGFR assessment; baseline urine albumin-to-creatinine ratio