Expressive

rs112702449 - LIMK1 - EIF4H

Magnitude 2.2 · 1 study on file

Reported associations

  • Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank. - Hernia : the journal of hernias and abdominal wall surgery (2022) · Wei J, Attaar M, Shi Z, Na R, Resurreccion WK, Haggerty SP, Zheng SL, Helfand BT, Ujiki MB, Xu J · PubMed 34382107

    Familial aggregation is known for both hernia development and recurrence. To date, only one genome-wide association study (GWAS) limited to inguinal hernia has been reported that identified four risk-associated loci. We aim to investigate polygenic architecture of abdominal wall hernia development and recurrence. A GWAS was performed in 367,394 subjects from the UK Biobank to investigate the polygenic architecture of abdominal wall hernia subtypes (inguinal, femoral, umbilical, ventral) and identify specific single nucleotide polymorphisms (SNPs) that are associated with their risk. Expression quantitative trait loci (eQTL) analysis was performed to identify genes whose expression levels are associated with these SNPs. A genetic risk score (GRS) was used to assess the cumulative effect of

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • inguinal hernia genetic risk screening Moderate

    Variant rs112702449 associated with 1.12-fold increased inguinal hernia risk in GWAS of 275,546 individuals

Lifestyle

  • chronic straining and constipation Moderate

    Chronic straining increases intra-abdominal pressure, compounding genetic predisposition to hernia

    Maintain regular bowel function via 25-30g fiber daily, adequate hydration, and regular exercise

  • heavy lifting without proper technique Moderate

    Increased intra-abdominal pressure from straining increases hernia risk, particularly relevant for genetically predisposed individuals

    Use proper lifting form; request assistance for items over 25 lbs; avoid repetitive straining

Screening

  • inguinal hernia symptoms Moderate

    Early detection and intervention can prevent complications in genetically predisposed individuals

    Report any new groin bulge, pain, or sensation of fullness to physician