Expressive

rs112667817 - RPL7P19 - ETF1

Magnitude 2.2 · 1 study on file

Reported associations

  • Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis - Unknown journal (n.d.) · Unknown authors · PubMed 32541925

    ABSTRACT: We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ethnic meta-analysis of 228,499 cases and 1,178,783 controls in the Million Veteran Program, DIAMANTE, Biobank Japan, and other studies. We report 568 associations, including 286 autosomal, 7 X chromosomal, and 25 identified in ancestry-specific analyses that were previously unreported. Transcriptome-wide association analysis detected 3,568 T2D-associations with genetically predicted gene expression in 687 novel genes; of these, 54 are known to interact with FDA-approved drugs. A polygenic risk score was strongly associated with increased risk of T2D-related retinopathy and modestly associated with chronic kidney disease (CKD), peripheral artery disease (PAD), and neuropathy. We investigated the genetic etiolo

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • refined carbohydrate restriction Moderate

    Limiting refined carbohydrates and added sugars reduces type 2 diabetes risk

    Reduce refined grains and added sugars; increase whole grains and fiber

Exercise

  • regular physical activity Moderate

    Physical activity improves insulin sensitivity and reduces type 2 diabetes risk

    150 minutes moderate or 75 minutes vigorous intensity per week

Screening

  • fasting glucose and HbA1c screening Moderate

    rs112667817 C allele associated with increased type 2 diabetes risk

    Annual fasting glucose or HbA1c; more frequent if prediabetic