rs11264327 - Y_RNA - EFNA1
Magnitude 2.2 · 1 study on file
Reported associations
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Genetic Association of Albuminuria with Cardiometabolic Disease and Blood Pressure. - American journal of human genetics (2019) · Haas ME, Aragam KG, Emdin CA, Bick AG, Hemani G, Davey Smith G, Kathiresan S · PubMed 30220432
Excretion of albumin in urine, or albuminuria, is associated with the development of multiple cardiovascular and metabolic diseases. However, whether pathways leading to albuminuria are causal for cardiometabolic diseases is unclear. We addressed this question using a Mendelian randomization framework in the UK Biobank, a large population-based cohort. We first performed a genome-wide association study for albuminuria in 382,500 individuals and identified 32 new albuminuria loci. We constructed albuminuria genetic risk scores and tested for association with cardiometabolic diseases. Genetically elevated albuminuria was strongly associated with increased risk of hypertension (1.38 OR; 95% CI, 1.27-1.50 per 1 SD predicted increase in albuminuria, p = 7.01 × 10 ). We then examined bidire
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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Dietary sodium restriction Moderate
Elevated albumin excretion increases kidney disease risk; dietary sodium reduction may slow progression
Maintain daily sodium intake below 2,300mg, targeting 1,500-2,000mg if tolerated
Screening
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Annual urinalysis with albumin-to-creatinine ratio Moderate
This variant is associated with increased urinary albumin excretion, an early sign of kidney disease
Measure urine albumin-to-creatinine ratio annually or as recommended by provider