rs11264322 - EFNA3 - Y_RNA
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration - Unknown journal (n.d.) · Unknown authors · PubMed 32242144
ABSTRACT: Vitamin D deficiency is a candidate risk factor for a range of adverse health outcomes. In a genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 Europeans we identify 143 independent loci in 112 1-Mb regions, providing insights into the physiology of vitamin D and implicating genes involved in lipid and lipoprotein metabolism, dermal tissue properties, and the sulphonation and glucuronidation of 25OHD. Mendelian randomization models find no robust evidence that 25OHD concentration has causal effects on candidate phenotypes (e.g. BMI, psychiatric disorders), but many phenotypes have (direct or indirect) causal effects on 25OHD concentration, clarifying the epidemiological relationship between 25OHD status and the health outcomes examined in this s
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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Serum 25-hydroxyvitamin D levels Moderate
This variant is associated with lower circulating vitamin D levels in large population studies.
Check serum 25-hydroxyvitamin D annually or as part of routine screening.
Supplements
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Vitamin D3 supplementation Moderate
Genetic association with reduced baseline vitamin D suggests potential benefit from targeted supplementation.
Supplement if serum 25-hydroxyvitamin D is below 30 ng/mL, typical dose 1000-4000 IU daily.