rs112621169 - SLC22A24

Magnitude 2.2 · 2 studies on file

Reported associations

• Testosterone and socioeconomic position: Mendelian randomization in 306,248 men and women in UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 34321204

  ABSTRACT: Mendelian randomization suggests circulating testosterone does not meaningfully affect men's socioeconomic position. Men with more advantaged socioeconomic position (SEP) have been observed to have higher levels of testosterone. It is unclear whether these associations arise because testosterone has a causal impact on SEP. In 306,248 participants of UK Biobank, we performed sex-stratified genome-wide association analysis to identify genetic variants associated with testosterone. Using the identified variants, we performed Mendelian randomization analysis of the influence of testosterone on socioeconomic position, including income, employment status, neighborhood-level deprivation, and educational qualifications; on health, including self-rated health and body mass index; and on

• Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine - Unknown journal (n.d.) · Unknown authors · PubMed 37277652

  ABSTRACT: The kidneys operate at the interface of plasma and urine by clearing molecular waste products while retaining valuable solutes. Genetic studies of paired plasma and urine metabolomes may identify underlying processes. We conducted genome-wide studies of 1,916 plasma and urine metabolites and detected 1,299 significant associations. Associations with 40% of implicated metabolites would have been missed by studying plasma alone. We detected urine-specific findings that provide information about metabolite reabsorption in the kidney, such as aquaporin (AQP)-7-mediated glycerol transport, and different metabolomic footprints of kidney-expressed proteins in plasma and urine that are consistent with their localization and function, including the transporters NaDC3 (SLC13A3) and ASBT (S

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