rs1126179 - LINC00922 - RNA5SP428

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide association study (GWAS) for molar-incisor hypomineralization (MIH). - Clinical oral investigations (2015) · Kühnisch J, Thiering E, Heitmüller D, Tiesler CM, Grallert H, Heinrich-Weltzien R, Hickel R, Heinrich J · PubMed 23918034

  This genome-wide association study (GWAS) investigated the relationship between molar-incisor hypomineralization (MIH) and possible genetic loci. Clinical and genetic data from the 10-year follow-up of 668 children from the Munich GINI-plus and LISA-plus birth cohort studies were analyzed. The dental examinations included the diagnosis of MIH according to the criteria of the European Academy of Paediatric Dentistry (EAPD). Children with MIH were categorized as those with a minimum of one hypomineralized first permanent molar. A GWAS was implemented following a quality-control step and an additive genetic effect was assumed. A total of 2,013,491 single-nucleotide polymorphisms (SNPs) were available for analysis. Rs13058467, which is located near the SCUBE1 gene on chromosome 22 (p < 3.72E-7

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.