Expressive

rs11260603 - LINC01342

Magnitude 2.2 · 2 studies on file

Reported associations

  • Polygenic Risk Scores and the Need for Pharmacotherapy in Neonatal Abstinence Syndrome - Unknown journal (n.d.) · Unknown authors · PubMed 35974158

    ABSTRACT: Objectives: To identify genetic variants associated with NAS through a Genome Wide Association Study (GWAS) and estimate a Polygenic Risk Score (PRS) model for NAS. Design: A prospective case-control study included 476 in-utero opioid-exposed term neonates. A GWAS of 1000 Genomes-imputed genotypes was performed to identify variants associated with need for pharmacotherapy for NAS. PRS models for estimating genetic predisposition were generated via a nested cross-validation approach using 382 neonates of European ancestry. PRS predictive ability, discrimination, and calibration were assessed. Results: Cross-ancestry GWAS identified one intergenic locus on chromosome 7 downstream of SNX13 exhibiting genome-wide association with need for pharmacotherapy. PRS models derived from the

  • Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological Cancers - Unknown journal (n.d.) · Unknown authors · PubMed 23382691

    ABSTRACT: Glycosylation of immunoglobulin G (IgG) influences IgG effector function by modulating binding to Fc receptors. To identify genetic loci associated with IgG glycosylation, we quantitated N-linked IgG glycans using two approaches. After isolating IgG from human plasma, we performed 77 quantitative measurements of N-glycosylation using ultra-performance liquid chromatography (UPLC) in 2,247 individuals from four European discovery populations. In parallel, we measured IgG N-glycans using MALDI-TOF mass spectrometry (MS) in a replication cohort of 1,848 Europeans. Meta-analysis of genome-wide association study (GWAS) results identified 9 genome-wide significant loci (P<2.27×10−9) in the discovery analysis and two of the same loci (B4GALT1 and MGAT3) in the replication cohort. Fou

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