Expressive

rs112586322 - BEND4 - SHISA3

Magnitude 4.5 · 1 study on file

Reported associations

  • Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits - Unknown journal (n.d.) · Unknown authors · PubMed 33603002

    ABSTRACT: Genome-wide association studies (GWAS) have identified thousands of genetic loci associated with cross-sectional blood pressure (BP) traits; however, GWAS based on longitudinal BP have been underexplored. We performed ethnic-specific and trans-ethnic GWAS meta-analysis using longitudinal and cross-sectional BP data of 33,720 individuals from five cohorts in the US and one in Brazil. In addition to identifying several known loci, we identified thirteen novel loci with nine based on longitudinal and four on cross-sectional BP traits. Most of the novel loci were ethnic- or study-specific, with the majority identified in African Americans (AA). Four of these discoveries showed additional evidence of association in independent datasets, including an intergenic variant (rs4060030, p 

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Sodium reduction Moderate

    Dietary sodium is a modifiable risk factor for blood pressure elevation; particularly relevant given genetic predisposition

    Target less than 2300mg sodium per day

Discuss with your doctor

  • Cardiovascular risk assessment Moderate

    Genetic predisposition to elevated blood pressure increases long-term cardiovascular disease risk and warrants proactive medical oversight

Exercise

  • Regular aerobic exercise Moderate

    Aerobic activity effectively reduces blood pressure; important given genetic predisposition to elevated baseline

    150 minutes moderate-intensity aerobic activity per week

Screening

  • Blood pressure monitoring Moderate

    Genetic variant increases systolic blood pressure by approximately 1.9 mmHg, warranting closer cardiovascular surveillance

    Annual blood pressure screening; more frequent if baseline elevated