Expressive

rs11258422 - BEND7

Magnitude 2.2 · 1 study on file

Reported associations

  • Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis - Unknown journal (n.d.) · Unknown authors · PubMed 32541925

    ABSTRACT: We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ethnic meta-analysis of 228,499 cases and 1,178,783 controls in the Million Veteran Program, DIAMANTE, Biobank Japan, and other studies. We report 568 associations, including 286 autosomal, 7 X chromosomal, and 25 identified in ancestry-specific analyses that were previously unreported. Transcriptome-wide association analysis detected 3,568 T2D-associations with genetically predicted gene expression in 687 novel genes; of these, 54 are known to interact with FDA-approved drugs. A polygenic risk score was strongly associated with increased risk of T2D-related retinopathy and modestly associated with chronic kidney disease (CKD), peripheral artery disease (PAD), and neuropathy. We investigated the genetic etiolo

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • prioritize whole grains, limit refined carbohydrates Moderate

    BEND7 reduced expression in glucose-handling tissues means refined carbs with high glycemic load may amplify dysregulation

    replace white bread and white rice with whole grain alternatives; minimize sugar-sweetened beverages

Exercise

  • aerobic and resistance exercise Moderate

    BEND7 eQTL in skeletal muscle and blood suggests genotype-dependent glucose utilization; physical activity restores insulin sensitivity

    150 minutes moderate-intensity aerobic activity weekly plus 2-3 days of resistance training

Screening

  • type 2 diabetes screening Moderate

    C allele increases type 2 diabetes risk via reduced BEND7 expression in glucose-metabolizing tissues, impairing glucose homeostasis

    baseline fasting glucose and HbA1c; repeat annually until prediabetes is ruled out