rs112581665 - TUBG1 - ATP5MGP7
Magnitude 2.2 · 1 study on file
Reported associations
-
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449
ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
-
increased genetic risk for type 2 diabetes Moderate
variant increases risk for fasting glucose elevation, HbA1c elevation, and type 2 diabetes based on large genome-wide association study
discuss with primary care provider to determine appropriate screening frequency and preventive care strategy
Screening
-
fasting glucose and HbA1c screening Moderate
genetic variant increases fasting glucose levels and HbA1c, early indicators of glucose dysregulation and type 2 diabetes risk
annual fasting glucose or HbA1c testing; baseline screening if not completed