rs1125777 - NFIA; NFIA; NFIA

Magnitude 4.5 · 1 study on file

Reported associations

• A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder - Unknown journal (n.d.) · Unknown authors · PubMed 22925353

  ABSTRACT: Objective: The use of subphenotypes may be an effective approach for genetic studies of complex diseases. Manic episodes with a seasonal pattern may distinguish phenotypic subgroups of bipolar subjects that may also differ genetically. Method: We have performed a genome-wide association study using GAIN genotype data from the Bipolar Genome Study (BiGS) and bipolar subjects that were categorized as having either seasonal or non-seasonal patterned manic episodes. Results: A bipolar case-only analysis identified three genomic regions that differed between seasonal and non-seasonal patterned manic episodes of bipolar subjects. The most significant association was for rs41350144, which lies within an intron of NF1A gene on 1p31 (P=3.08 × 10−7, OR=2.27). Haplotype construction usin

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