Expressive

rs112572874 - MAPT

Magnitude 2.2 · 3 studies on file

Reported associations

  • Genetic risk factors and COVID-19 severity in Brazil: results from BRACOVID study. - Human molecular genetics (2022) · Pereira AC, Bes TM, Velho M, Marques E, Jannes CE, Valino KR, Dinardo CL, Costa SF, Duarte AJS, Santos AR, Mitne-Neto M, Medina-Pestana J, Krieger JE · PubMed 35368071

    The coronavirus disease 2019 (COVID-19) pandemic has changed the paradigms for disease surveillance and rapid deployment of scientific-based evidence for understanding disease biology, susceptibility and treatment. We have organized a large-scale genome-wide association study (GWAS) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected individuals in Sao Paulo, Brazil, one of the most affected areas of the pandemic in the country, itself one of the most affected in the world. Here, we present the results of the initial analysis in the first 5233 participants of the BRACOVID study. We have conducted a GWAS for COVID-19 hospitalization enrolling 3533 cases (hospitalized COVID-19 participants) and 1700 controls (non-hospitalized COVID-19 participants). Models were adjusted

  • Regulatory Genomic Circuitry of Brain Age by Integrative Functional Genomic Analyses - Unknown journal (n.d.) · Unknown authors · PubMed 40795387

    ABSTRACT: Abstract Brain age gap (BAG) is a valuable biomarker for evaluating brain healthy status and detecting age-associated cognitive degeneration. However, the genetic architecture of BAG and the underlying mechanisms are poorly understood. Here, we estimated brain age from magnetic resonance imaging with improved accuracy using our proposed adversarial convolution network (ACN), and applied the ACN model to an elderly cohort from the UK Biobank. The genetic heritability of BAG was significantly enriched in regulatory regions and implicated in glial cells. We prioritized a set of BAG-associated genes, and further characterized their expression patterns across brain cell types and regions. Two BAG-associated genes, RUNX2 and KLF3, were found to be associated with epigenetic clock and d

  • Testosterone and socioeconomic position: Mendelian randomization in 306,248 men and women in UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 34321204

    ABSTRACT: Mendelian randomization suggests circulating testosterone does not meaningfully affect men's socioeconomic position. Men with more advantaged socioeconomic position (SEP) have been observed to have higher levels of testosterone. It is unclear whether these associations arise because testosterone has a causal impact on SEP. In 306,248 participants of UK Biobank, we performed sex-stratified genome-wide association analysis to identify genetic variants associated with testosterone. Using the identified variants, we performed Mendelian randomization analysis of the influence of testosterone on socioeconomic position, including income, employment status, neighborhood-level deprivation, and educational qualifications; on health, including self-rated health and body mass index; and on

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