rs1125718 - MTCO1P49 - ZFAT

Magnitude 2.0 · 1 study on file

Reported associations

• Metabolomic signatures for the longitudinal reduction of muscle strength over 10 years - Skeletal muscle (2022) · Werdyani S, Aitken D, Gao Z, Liu M, Randell EW, Rahman P, Jones G, Zhai G · PubMed 35130970

  ABSTRACT: Background Skeletal muscles are essential components of the neuromuscular skeletal system that have an integral role in the structure and function of the synovial joints which are often affected by osteoarthritis (OA). The aim of this study was to identify the baseline metabolomic signatures for the longitudinal reduction of muscle strength over 10 years in the well-established community-based Tasmanian Older Adult Cohort (TASOAC). Methods Study participants were 50-79 year old individuals from the TASOAC. Hand grip, knee extension, and leg strength were measured at baseline, 2.6-, 5-, and 10-year follow-up points. Fasting serum samples were collected at 2.6-year follow-up point, and metabolomic profiling was performed using the TMIC Prime Metabolomics Profiling Assay. Gene

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