rs11256442 - IL2RA

Magnitude 2.2 · 1 study on file

Reported associations

• A type 1 diabetes genetic risk score discriminates between type 1 diabetes and type 2 diabetes in a Chinese population - Unknown journal (n.d.) · Unknown authors · PubMed 40569436

  ABSTRACT: Aims/hypothesis We aimed to generate a population-specific type 1 diabetes genetic risk score (GRS) and assess whether it could improve discrimination between type 1 diabetes and type 2 diabetes in a Chinese population. Methods We performed a genome-wide association analysis on 1303 individuals with type 1 diabetes and 2236 control individuals. An independent replication cohort of 501 individuals with type 1 diabetes and 853 control individuals was used to validate the top common variant associations. HLA typing data were used to identify tag SNPs for DQA1-DQB1 haplotypes. We integrated significant signals to construct a Chinese type 1 diabetes GRS (C-GRS). The accuracy of the C-GRS was tested in an independent validation cohort consisting of 262 individuals with type 1 diabetes,

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