Expressive

rs11256258 - IL15RA - IL2RA

Magnitude 2.0 · 2 studies on file

Reported associations

  • Heritability and genome‐wide association study of blood pressure in Chinese adult twins - Molecular genetics & genomic medicine (2022) · Chen J, Wang W, Li Z, Xu C, Tian X, Zhang D · PubMed 34586716

    ABSTRACT: Abstract Background Blood pressure (BP) is an independent and important factor for chronic diseases such as cardiovascular diseases and diabetes. Methods We firstly conducted twin modeling analyses to explore the heritability of BP, including systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP) and mean arterial pressure (MAP), and then performed genome‐wide association studies to explore the associated genomic loci, genes, and pathways. Results A total of 380 Chinese twin pairs were included. The AE model containing additive genetic parameter (A) and unique/non‐shared environmental parameter (E) was the best fit model, with A accounting for 53.7%, 50.1%, 48.1%, and 53.3% for SBP, DBP, PP and MAP, respectively. No SNP was found to reach the genom

  • Bivariate genome-wide association study (GWAS) of body mass index and blood pressure phenotypes in northern Chinese twins - PloS one (2021) · Li Z, Wang W, Tian X, Duan H, Xu C, Zhang D · PubMed 33539483

    ABSTRACT: Recently, new loci related to body mass index (BMI) or blood pressure (BP) have been identified respectively in genome-wide association studies (GWAS). However, limited studies focused on jointly associated genetic variance between systolic pressure (SBP), diastolic pressure (DBP) and BMI. Therefore, a bivariate twin study was performed to explore the genetic variants associated with BMI-SBP, BMI-DBP and SBP-DBP. A total of 380 twin pairs (137 dizygotic pairs and 243 monozygotic pairs) recruited from Qingdao Twin Registry system were used to access the genetic correlations (0.2108 for BMI-SBP, 0.2345 for BMI-DBP, and 0.6942 for SBP-DBP, respectively) by bivariate Cholesky decomposition model. Bivariate GWAS in 137 dizygotic pairs nominated 27 single identified 27 quantitative tra

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