rs11255507 - GATA3
Magnitude 2.2 · 1 study on file
Reported associations
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Discerning asthma endotypes through comorbidity mapping - Unknown journal (n.d.) · Unknown authors · PubMed 36344522
ABSTRACT: Asthma is a heterogeneous, complex syndrome, and identifying asthma endotypes has been challenging. We hypothesize that distinct endotypes of asthma arise in disparate genetic variation and life-time environmental exposure backgrounds, and that disease comorbidity patterns serve as a surrogate for such genetic and exposure variations. Here, we computationally discover 22 distinct comorbid disease patterns among individuals with asthma (asthma comorbidity subgroups) using diagnosis records for >151 M US residents, and re-identify 11 of the 22 subgroups in the much smaller UK Biobank. GWASs to discern asthma risk loci for individuals within each subgroup and in all subgroups combined reveal 109 independent risk loci, of which 52 are replicated in multi-ancestry meta-analysis acro
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic asthma risk and screening strategy Moderate
Carriers of the GATA3 G allele have 1.055-fold increased asthma risk; discussion enables tailored prevention.
Bring up at next healthcare visit
Lifestyle
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respiratory symptoms and air quality exposure Moderate
Heightened genetic asthma risk makes symptom awareness and environmental monitoring valuable for early intervention.
Note cough, wheeze, or shortness of breath; consider air quality checks before outdoor activity
Screening
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baseline asthma symptom assessment Moderate
Genetic predisposition warrants baseline evaluation to establish asthma status before symptoms develop.
Spirometry or standardized asthma symptom questionnaire