rs112533663 - LINC00598, LINC00332
Magnitude 2.2 · 1 study on file
Reported associations
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Large-scale cross-ancestry genome-wide meta-analysis of serum urate - Unknown journal (n.d.) · Unknown authors · PubMed 38658550
ABSTRACT: Hyperuricemia is an essential causal risk factor for gout and is associated with cardiometabolic diseases. Given the limited contribution of East Asian ancestry to genome-wide association studies of serum urate, the genetic architecture of serum urate requires exploration. A large-scale cross-ancestry genome-wide association meta-analysis of 1,029,323 individuals and ancestry-specific meta-analysis identifies a total of 351 loci, including 17 previously unreported loci. The genetic architecture of serum urate control is similar between European and East Asian populations. A transcriptome-wide association study, enrichment analysis, and colocalization analysis in relevant tissues identify candidate serum urate-associated genes, including CTBP1, SKIV2L, and WWP2. A phenome-wide ass
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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Serum urate baseline level High
rs112533663 is genome-wide significantly associated with elevated serum urate, a metabolic marker linked to gout and cardiometabolic disease risk.
Request serum urate measurement if not recently checked.
Discuss with your doctor
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Personalized urate management and prevention plan High
Genetic predisposition to elevated serum urate increases risk for gout, hypertension, kidney disease, and cardiovascular disease. A prevention strategy tailored to urate levels can reduce disease incidence.
Share this genetic finding with your healthcare provider and discuss monitoring frequency and prevention strategies.