Expressive

rs112515915 - ZFPM2

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genetic drivers of heterogeneity in type 2 diabetes pathophysiology - Unknown journal (n.d.) · Unknown authors · PubMed 38374256

    ABSTRACT: Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes and molecular mechanisms that are often specific to cell type. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P < 5 × 10−8) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-sp

  • Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis - Unknown journal (n.d.) · Unknown authors · PubMed 32541925

    ABSTRACT: We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ethnic meta-analysis of 228,499 cases and 1,178,783 controls in the Million Veteran Program, DIAMANTE, Biobank Japan, and other studies. We report 568 associations, including 286 autosomal, 7 X chromosomal, and 25 identified in ancestry-specific analyses that were previously unreported. Transcriptome-wide association analysis detected 3,568 T2D-associations with genetically predicted gene expression in 687 novel genes; of these, 54 are known to interact with FDA-approved drugs. A polygenic risk score was strongly associated with increased risk of T2D-related retinopathy and modestly associated with chronic kidney disease (CKD), peripheral artery disease (PAD), and neuropathy. We investigated the genetic etiolo

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Weight management and limit refined carbohydrates Moderate

    Weight control and low glycemic index diet reduce Type 2 diabetes incidence

    Target BMI <25; minimize added sugars and processed foods

Discuss with your doctor

  • Type 2 diabetes risk and prevention strategies High

    Genetic predisposition identified in multiple large GWAS studies warrants individualized risk assessment

Lifestyle

  • Regular physical activity for metabolic health Moderate

    Physical activity improves insulin sensitivity and reduces Type 2 diabetes risk

    150 minutes moderate-intensity aerobic activity per week

Screening

  • Type 2 diabetes screening (HbA1c, fasting glucose) High

    Genetic variant strongly associated with increased Type 2 diabetes risk

    Baseline screening by age 30, then annually or per physician guidance