rs112515516 - HLA-B

Magnitude 2.2 · 1 study on file

Reported associations

• Multiancestry Genome-Wide Association Study Identifies Variants in a Zinc Finger Gene Cluster as Novel Regulators of HIV Control. - The Journal of infectious diseases (2026) · Awada A, Tough RH, Fellay J, McLaren PJ · PubMed 41640362

  Human immunodeficiency virus 1 (HIV-1) remains a global health challenge, emphasizing the need to identify new host factors that influence pathogenesis to serve as drug targets. Identifying genetic determinants of HIV-1 control across diverse populations remains a top priority. We conducted a multiancestry genome-wide association study (GWAS) of HIV-1 set-point viral load (spVL) leveraging genotype and viral load data from 10 723 individuals with HIV-1. To prioritize candidate genes and mechanisms, we integrated GWAS findings with transcriptome-wide association study (TWAS) and expression quantitative trait loci (eQTL) data. We implicate the potential role of zinc finger proteins in pathogenesis through identification of a novel signal in the zinc finger protein 586 (ZNF586) gene on chromo

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