Expressive

rs11248862 - UBE2I-AS1, UBE2I

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genetic analysis of over one million people identifies 535 new loci associated with blood pressure traits - Unknown journal (n.d.) · Unknown authors · PubMed 30224653

    ABSTRACT: High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic, pulse pressure) to date in over one million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also reveal shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future. FULL TEXT: [INTRO] Introduction [INTRO] High blood pressure (BP) is a leading heritable risk factor for stroke and coronary artery disease, responsible for an es

  • High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study - Unknown journal (n.d.) · Unknown authors · PubMed 35762941

    ABSTRACT: Purpose To test for causality with regard to the association between blood pressure (BP) and intraocular pressure (IOP) and glaucoma. Methods Single nucleotide polymorphisms (SNPs) associated with BP were identified in a genome-wide association study (GWAS) meta-analysis of 526,001 participants of European ancestry. These SNPs were used to assess the BP versus IOP relationship in a distinct sample (n = 70,832) whose corneal-compensated IOP (IOPcc) was measured. To evaluate the BP versus primary open-angle glaucoma (POAG) relationship, additional Mendelian randomization (MR) analyses were conducted using published GWAS summary statistics. Results Observational analysis revealed a linear relationship between BP traits and IOPcc, with a +0.28 mm Hg increase in IOPcc per 10-mm Hg inc

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • cardiovascular risk assessment and pulse pressure Moderate

    Variant is strongly associated with elevated pulse pressure, affecting cardiovascular physiology in arterial and cardiac tissues.

    Discuss screening protocols and risk reduction strategies with healthcare provider

Screening

  • blood pressure and pulse pressure Moderate

    Variant is strongly associated with elevated pulse pressure, an independent cardiovascular risk factor.

    Annual blood pressure screening, assess pulse pressure systematically