rs1124874 - LINC02702

Magnitude 2.2 · 1 study on file

Reported associations

• Cross-trait genomic modeling reveals the polygenic architecture and systemic impact of MASLD - Unknown journal (n.d.) · Unknown authors · PubMed 41686896

  ABSTRACT: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a globally prevalent disease, yet its genetic architecture remains incompletely characterized. We integrated genome-wide association study data from multiple cohorts totaling nearly 3 million individuals of European ancestry and applied cross-trait genomic modeling of hepatic fat and seven cardiometabolic traits to construct an MASLD-specific polygenic architecture. We identified 128 risk variants across 100 loci and prioritized 55 effector genes, including established (e.g., PNPLA3 and TM6SF2) and previously unreported candidates (e.g., NRXN3 and FRMD5). A phenome-wide scan of the MASLD polygenic risk score revealed broad associations spanning hepatic, cardiometabolic, renal, endocrine, and neuropsychiatric sy

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