rs11246969 - NOC4L - LINC02361

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide Association and Multi-Omics Studies Identify MGMT as a Novel Risk Gene for Alzheimer Disease Among Women - Unknown journal (n.d.) · Unknown authors · PubMed 35770850

  ABSTRACT: INTRODUCTION: Variants in the tau gene (MAPT) region are associated with breast cancer in women and Alzheimer disease (AD) among persons lacking APOE ε4 (ε4-). METHODS: To identify novel genes associated with tau-related pathology, we conducted two genome-wide association studies (GWAS) for AD, one among 10,340 ε4- women in the Alzheimer's Disease Genetics Consortium (ADGC) and another in 31 members (22 women) of a consanguineous Hutterite kindred. RESULTS: We identified novel associations of AD with MGMT variants in ADGC (rs12775171, odds ratio [OR]=1.4, P=4.9×10−8) and Hutterites (rs12256016 and rs2803456, OR=2.0, P=1.9×10−14). Multi-omics analyses showed that the most significant and largest number of associations among the SNPs, DNA-methylated CpGs, MGMT expression

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