rs11246045 - COX8BP - NLRP6

Magnitude 2.2 · 1 study on file

Reported associations

• A large-scale genome-wide association study on female genital tract polyps highlights role of DNA repair, cell proliferation, and cell growth. - Human reproduction (Oxford, England) (2025) · Pathare ADS, Džigurski J, Pujol-Gualdo N, Rukins V, Peters M, Mägi R, Salumets A, Saare M, Laisk T · PubMed 39986329

  Can a large-scale genome-wide association study (GWAS) meta-analysis identify genomic risk loci and likely involved genes for female genital tract (FGT) polyps, provide insights into the biological mechanism underlying their development, and inform of potential overlap with other traits, including endometrial cancer? GWAS meta-analysis of FGT polyps highlights potentially shared mechanisms between polyp development and cancerous processes. Small-scale candidate gene studies have focused on biological processes such as oestrogen stimulation and inflammation to clarify the biology behind FGT polyps. However, the exact mechanism for the development of polyps is still elusive. At the same time, a genome-wide approach, which has become the gold standard in complex disease genetics, has never be

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