rs11246015 - SIRT3
Magnitude 2.2 · 1 study on file
Reported associations
-
Interactions between Polygenetic Variants and Lifestyle Factors in Hypothyroidism: A Hospital-Based Cohort Study - Unknown journal (n.d.) · Unknown authors · PubMed 37686882
ABSTRACT: Hypothyroidism is a prevalent endocrine disorder and is associated with a variety of metabolic disturbances. This study aimed to investigate the polygenic variants associated with hypothyroidism risk and the interaction of polygenic risk scores (PRS) with dietary patterns in influencing disease risk in 56,664 participants aged >40 in a hospital-based cohort. The participants were classified as having hypothyroidism (n = 870) diagnosed by a physician and no hypothyroidism (n = 55,794). Genetic variants associated with hypothyroidism were identified using a genome-wide association study (GWAS). Genetic variants interacting with each other were selected using a generalized multifactor dimensionality reduction analysis, and the PRS generated was evaluated for interaction with lifesty
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
-
dietary balance with plant and animal sources Moderate
Study found plant-based diet alone increased hypothyroidism risk in high genetic risk group; balanced diet including both plant and animal foods was protective
Include varied foods from plant and animal sources: lean meat, fish, eggs, whole grains, legumes, vegetables, fruits
-
selenium, copper, manganese, zinc intake Moderate
These minerals are cofactors for antioxidant enzymes; SIRT3 regulates mitochondrial stress response and study found lower intake associated with increased hypothyroidism risk
Assess dietary intake; target selenium 55 mcg/day, copper 900 mcg/day, zinc 8-11 mg/day; test if deficient
Discuss with your doctor
-
genetic risk for hypothyroidism prevention Moderate
SIRT3 rs11246015 is part of 7-SNP interaction model for hypothyroidism; discussing genetic predisposition enables personalized monitoring and preventive strategies
Share finding with doctor; discuss family history and symptoms; develop personalized screening plan
Lifestyle
-
smoking Moderate
Smoking status interacted with genetic risk to increase hypothyroidism risk significantly; smokers had higher risk across all PRS categories
If current smoker, pursue cessation; if non-smoker, maintain abstinence
Screening
-
TSH and thyroid hormone screening Moderate
rs11246015 in SIRT3 is associated with increased hypothyroidism risk in large cohort study; proactive screening enables early detection and treatment
Baseline TSH and free T4 testing; annual or biannual if normal; more frequent if symptoms or family history