rs11246003 - RIC8A
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis - Unknown journal (n.d.) · Unknown authors · PubMed 31649266
ABSTRACT: Uterine leiomyomata (UL) are the most common neoplasms of the female reproductive tract and primary cause for hysterectomy, leading to considerable morbidity and high economic burden. Here we conduct a GWAS meta-analysis in 35,474 cases and 267,505 female controls of European ancestry, identifying eight novel genome-wide significant (P < 5 × 10−8) loci, in addition to confirming 21 previously reported loci, including multiple independent signals at 10 loci. Phenotypic stratification of UL by heavy menstrual bleeding in 3409 cases and 199,171 female controls reveals genome-wide significant associations at three of the 29 UL loci: 5p15.33 (TERT), 5q35.2 (FGFR4) and 11q22.3 (ATM). Four loci identified in the meta-analysis are also associated with endometriosis risk; an ep
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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uterine fibroid screening and monitoring Moderate
Genetic variant T allele strongly associated with increased uterine fibroid risk across large population studies
discuss screening approach with gynecologist, including baseline ultrasound and monitoring for symptoms