rs11245979 - MUC2 - MUC5AC

Magnitude 2.2 · 1 study on file

Reported associations

• The genetic architecture of pneumonia susceptibility implicates mucin biology and a relationship with psychiatric illness - Unknown journal (n.d.) · Unknown authors · PubMed 35768473

  ABSTRACT: Pneumonia remains one of the leading causes of death worldwide. In this study, we use genome-wide meta-analysis of lifetime pneumonia diagnosis (N = 391,044) to identify four association signals outside of the previously implicated major histocompatibility complex region. Integrative analyses and finemapping of these signals support clinically tractable targets, including the mucin MUC5AC and tumour necrosis factor receptor superfamily member TNFRSF1A. Moreover, we demonstrate widespread evidence of genetic overlap with pneumonia susceptibility across the human phenome, including particularly significant correlations with psychiatric phenotypes that remain significant after testing differing phenotype definitions for pneumonia or genetically conditioning on smoking behaviour.

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