rs112457525 - HLA-DRA - HLA-DRB9

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide meta-analysis in lichen sclerosus identifies 14 genomic risk loci. - The British journal of dermatology (2026) · Dand N, Rayinda T, Silz E, Thomas LF, Saklatvala JR, McSweeney SM, Ung CY, Christou E, Lewis F, Kettunen J, Huilaja L, Brumpton BM, Hveem K, Løset M, Tasanen K, McGrath JA, Simpson MA, Tziotzios C · PubMed 41850335

  Lichen sclerosus (LS) is a common and highly debilitating chronic inflammatory dermatosis that primarily affects genital skin in both females and males. Despite the utility of large genetic studies to reveal pathogenic mechanisms and suggest novel therapeutic targets, the genetic basis of LS remains largely unstudied. To identify genomic loci at which common genetic variation influences LS susceptibility and establish associated pathogenic mechanisms. Sex-stratified genome-wide association studies of genital LS were performed in three European biobanks (UK Biobank, the Trøndelag Health Study [HUNT] and FinnGen). LS cases were primarily identified via linked electronic health records from primary and/or secondary care. In total 6,681 female cases and 407,255 controls were included, with 97

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