rs11243373 - PLPP7 - PRRC2B

Magnitude 2.2 · 1 study on file

Reported associations

• A genome-wide association study identifies 25(OH)D3-associated genetic variants in the prediabetic Chinese population. - Endocrine (2024) · Wang F, Yu J, Lin L, Lin D, Chen K, Quan H · PubMed 38291318

  Diabetes mellitus has been a significant public health problem, associated with high rates of morbidity, disability, and mortality. Prediabetes is a crucial period for preventing and managing diabetes. 25(OH)D3 is an important risk factor for prediabetes. However, there is limited genetic knowledge of 25(OH)D3 in the Chinese population. This study was designed to identify genetic variants associated with 25(OH)D3 and explore the potential pathogenesis of prediabetes. In this study, 451 individuals with prediabetes were recruited to determine the genetic variants associated with 25(OH)D3 through a genome-wide association study (GWAS). Gene mapping and overrepresentation analysis (ORA) were further performed to explore the candidate genes and their biological mechanisms. In this study, we id

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