rs11243149 - SSR1
Magnitude 2.2 · 2 studies on file
Reported associations
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Shared genetics of psychiatric disorders and type 2 diabetes:a large-scale genome-wide cross-trait analysis. - Journal of psychiatric research (2023) · Ding H, Xie M, Wang J, Ouyang M, Huang Y, Yuan F, Jia Y, Zhang X, Liu N, Zhang N · PubMed 36738649
Individuals with psychiatric disorders have elevated rates of type 2 diabetes comorbidity. Although little is known about the shared genetics and causality of this association. Thus, we aimed to investigate shared genetics and causal link between different type 2 diabetes and psychiatric disorders. We conducted a large-scale genome-wide cross-trait association study(GWAS) to investigate genetic overlap between type 2 diabetes and anorexia nervosa, attention deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depressive disorder, obsessive-compulsive disorder, schizophrenia, anxiety disorders and Tourette syndrome. By post-GWAS functional analysis, we identify variants genes expression in various tissues. Enrichment pathways, potential protein interaction and m
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Metabolomic investigation of major depressive disorder identifies a potentially causal association with polyunsaturated fatty acids - Unknown journal (n.d.) · Unknown authors · PubMed 36764567
ABSTRACT: Background: Metabolic differences have been reported between individuals with and without Major Depressive Disorder (MDD), but their consistency and causal relevance has been unclear. Methods: We conducted a metabolome-wide association study of MDD with 249 metabolomic measures available in UK Biobank (N = 29, 757). We then applied 2-sample bidirectional Mendelian Randomisation (MR) and colocalization analysis to identify potentially causal relationships between each metabolite and MDD. Results: One hundred and ninety-one metabolites tested were significantly associated with MDD (PFDR < 0.05), which reduced to 129 after adjustment for likely confounders. Lower abundance of Omega-3 fatty acid measures and a higher Omega-6: Omega-3 ratio showed potentially causal effects on liabili
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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regular physical activity and diet for glucose control Moderate
Lifestyle interventions reduce diabetes risk and improve glucose metabolism, particularly relevant given elevated glucose association.
150 minutes moderate aerobic activity per week and Mediterranean or DASH diet pattern
Screening
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baseline psychiatric evaluation Moderate
rs11243149 associates with anorexia nervosa, schizophrenia, and obsessive-compulsive disorder at genome-wide significance.
Discuss with healthcare provider about baseline psychiatric screening
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fasting glucose and HbA1c Moderate
rs11243149 associates with elevated fasting glucose levels, suggesting increased type 2 diabetes risk.
Annual or biennial fasting glucose and HbA1c testing