rs11243081 - F13A1 - LY86-AS1

Magnitude 2.2 · 1 study on file

Reported associations

• Ischemic Stroke Is Associated with the ABO Locus: The EuroCLOT Study - Unknown journal (n.d.) · Unknown authors · PubMed 23381943

  ABSTRACT: Objective End-stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischemic stroke. We explored whether genetic variants associated with end-stage coagulation in healthy REFVIDunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype. Methods Common genetic variants identified through genome-wide association studies of coagulation factors and fibrin structure/function in healthy twins (n = 2,100, Stage 1) were examined in ischemic stroke (n = 4,200 cases) using 2 independent samples of European ancestry (Stage 2). A third clinical collection having stroke subtyping (total 8,900 cases, 55,000 controls) was used for replication (Stage 3). Results Stage 1 identified 524 single nucleotide p

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