rs112426408 - AKT3 - LINC02774

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association and transcriptome analysis suggests total serum ghrelin to be linked with GFRAL. - European journal of endocrinology (2021) · Wittekind DA, Scholz M, Kratzsch J, Löffler M, Horn K, Kirsten H, Witte V, Villringer A, Kluge M · PubMed 33852427

  Ghrelin is an orexigenic peptide hormone involved in the regulation of energy homeostasis, food intake and glucose metabolism. Serum levels increase anticipating a meal and fall afterwards. Underlying genetic mechanisms of the ghrelin secretion are unknown. Total serum ghrelin was measured in 1501 subjects selected from the population-based LIFE-ADULT-sample after an overnight fast. A genome-wide association study (GWAS) was performed. Gene-based expression association analyses (transcriptome-wide association study (TWAS)) are statistical tests associating genetically predicted expression to a certain trait and were done using MetaXcan. In the GWAS, three loci reached genome-wide significance: the WW-domain containing the oxidoreductase-gene (WWOX; P = 1.80E-10) on chromosome 16q23.3-24.1

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