rs1124241 - MMS22L
Magnitude 2.2 · 1 study on file
Reported associations
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Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk - Unknown journal (n.d.) · Unknown authors · PubMed 39366959
ABSTRACT: Lung cancer remains the leading cause of cancer mortality, despite declining smoking rates. Previous lung cancer GWAS have identified numerous loci, but separating the genetic risks of lung cancer and smoking behavioral susceptibility remains challenging. Here, we perform multi-ancestry GWAS meta-analyses of lung cancer using the Million Veteran Program cohort (approximately 95% male cases) and a previous study of European-ancestry individuals, jointly comprising 42,102 cases and 181,270 controls, followed by replication in an independent cohort of 19,404 cases and 17,378 controls. We then carry out conditional meta-analyses on cigarettes per day and identify two novel, replicated loci, including the 19p13.11 pleiotropic cancer locus in squamous cell lung carcinoma. Overall, we
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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MMS22L DNA repair variant and lung cancer risk Moderate
rs1124241 in MMS22L impairs double-strand break repair and increases lung cancer risk independent of environmental factors.
Discuss genetic contribution to lung cancer risk and whether personalized screening protocols are appropriate.
Screening
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Lung cancer screening discussion Moderate
A allele at rs1124241 increases lung cancer risk via impaired DNA double-strand break repair, independent of smoking status.
If carrying A allele, discuss with healthcare provider about age-appropriate lung cancer screening options.