rs11242115 - IRF1
Magnitude 2.2 · 1 study on file
Reported associations
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High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study - Unknown journal (n.d.) · Unknown authors · PubMed 35762941
ABSTRACT: Purpose To test for causality with regard to the association between blood pressure (BP) and intraocular pressure (IOP) and glaucoma. Methods Single nucleotide polymorphisms (SNPs) associated with BP were identified in a genome-wide association study (GWAS) meta-analysis of 526,001 participants of European ancestry. These SNPs were used to assess the BP versus IOP relationship in a distinct sample (n = 70,832) whose corneal-compensated IOP (IOPcc) was measured. To evaluate the BP versus primary open-angle glaucoma (POAG) relationship, additional Mendelian randomization (MR) analyses were conducted using published GWAS summary statistics. Results Observational analysis revealed a linear relationship between BP traits and IOPcc, with a +0.28 mm Hg increase in IOPcc per 10-mm Hg inc
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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personalized blood pressure management strategy Moderate
Genetic association with higher diastolic BP warrants discussion of individual BP prevention strategy
Discuss screening interval and management options during routine visit
Lifestyle
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lifestyle modifications for blood pressure control Moderate
Healthy lifestyle supports BP management in those with genetic BP predisposition
Regular aerobic exercise, sodium restriction, weight management, stress management, limit alcohol
Screening
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diastolic blood pressure Moderate
rs11242115 C allele associates with increased diastolic BP across 526K individuals (effect 0.182 mmHg, p=9e-17)
Annual blood pressure measurement; consider more frequent monitoring if elevated