rs112367251 - RALGPS1
Magnitude 2.2 · 1 study on file
Reported associations
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The genetic architecture of appendicular lean mass characterized by association analysis in the UK Biobank study - Unknown journal (n.d.) · Unknown authors · PubMed 33097823
ABSTRACT: Appendicular lean mass (ALM) is a heritable trait associated with loss of lean muscle mass and strength, or sarcopenia, but its genetic determinants are largely unknown. Here we conducted a genome-wide association study (GWAS) with 450,243 UK Biobank participants to uncover its genetic architecture. A total of 1059 conditionally independent variants from 799 loci were identified at the genome-wide significance level (p < 5 × 10−9), all of which were also significant at p < 5 × 10-5 in both sexes. These variants explained ~15.5% of the phenotypic variance, accounting for more than one quarter of the total ~50% GWAS-attributable heritability. There was no difference in genetic effect between sexes or among different age strata. Heritability was enriched in cer
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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Adequate protein intake for muscle synthesis Moderate
Genetic predisposition to lean muscle mass requires adequate dietary protein to actualize muscle-building potential
Aim for 1.2-2.0g protein per kilogram of body weight daily
Exercise
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Resistance training for lean muscle development Moderate
RALGPS1 rs112367251 is associated with increased appendicular lean mass, indicating greater muscle-building potential with resistance exercise
Perform 2-3 sessions per week of progressive resistance training targeting major muscle groups