rs112346568 - CD207 - LINC01143
Magnitude 2.2 · 1 study on file
Reported associations
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Integration of GWAS, QTLs and keratinocyte functional assays reveals molecular mechanisms of atopic dermatitis - Unknown journal (n.d.) · Unknown authors · PubMed 40164604
ABSTRACT: Atopic dermatitis is a highly heritable and common inflammatory skin condition affecting children and adults worldwide. Multi-ancestry approaches to atopic dermatitis genetic association studies are poised to boost power to detect genetic signal and identify loci contributing to atopic dermatitis risk. Here, we present a multi-ancestry GWAS meta-analysis of twelve atopic dermatitis cohorts from five ancestral populations totaling 56,146 cases and 602,280 controls. We report 101 genomic loci associated with atopic dermatitis, including 16 loci that have not been previously associated with atopic dermatitis or eczema. Fine-mapping, QTL colocalization, and cell-type enrichment analyses identified genes and cell types implicated in atopic dermatitis pathophysiology. Functional analys
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic atopic dermatitis risk and prevention strategy Moderate
GWAS association indicates increased AD susceptibility requiring informed preventive care planning
Lifestyle
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Daily skin moisturizing regimen Moderate
CD207 variants impair skin barrier function; proactive moisturizing reduces inflammatory triggers in atopic dermatitis
Apply moisturizer within 3 minutes after bathing, twice daily
Screening
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Atopic dermatitis development Moderate
This variant significantly increases atopic dermatitis risk through altered CD207-mediated skin barrier and immune function
Annual dermatological evaluation; earlier assessment if symptoms occur